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KMID : 0388620030150010026
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Molecular and Cellular Biology News
2003 Volume.15 No. 1 p.26 ~ p.36
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Signal Transduction by Cell Adhesion Receptors, Integrins
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Lee Jeong-Won
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Abstract
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Interactions of cells with basement membranes and the extracellular matrices are crucial for various biological processes, including the maintenance of tissue integrity, embryogenesis, wound healing, and the metastasis of tumor cells. These processes involve cell adhesion and migration. Adhesive and migratory events require certain biochemical entities, formation of multiprotein complex between these entities, and their functional communication one another. Cell adhesion is mediated through cell adhesion receptors or transmembrane glycoproteins binding to extracellular matrix (ECM) or counterreceptors on neighbor cells. Cell adhesion receptor families include cadherins, selectins, syndecans, and the immunoglobulin superfamily of cell adhesion molecules (IgCAMs
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